Brivaracetam (BRV), an analog of levetiracetam (LEV), was discovered during a target-
based rational drug discovery program that aimed to identify potent synaptic vesicle protein …

Abstract Purpose of Review Depression and anxiety substantially contribute to interictal
disability in patients with epilepsy (PWE). This review summarizes current studies that shed …

Introduction This multicenter, retrospective study aimed to evaluate the efficiency, retention,
safety, and tolerability of brivaracetam (BRV) in children and adolescents with focal epilepsy …

Purpose To assess short-term and longer-term effects of brivaracetam (BRV) on cognition
and behavior in a naturalistic clinical setting. Methods Analyses were based on 43 patients …

Purpose Kappa opioid receptor (KOR) agonists have anticonvulsant effect but their
antiepileptogenic effect is unknown. U50488, a selective KOR agonist is used to determine …

Anti‐seizure medications (ASMs) can cause cognitive or behavioral adverse drug reactions,
which is an important consideration when selecting an appropriate ASM. Brivaracetam …

Several studies with larvae and adult zebrafish have shown that old and new antiseizure
drugs (ASDs) produce discrepant results in seizure tests, locomotor activity or anxiety …

Purpose The rate of brivaracetam-related behavioural adverse events is a current focus of
discussion. This study aims to assess the effect of brivaracetam on anger levels in patients …

Objective One of the newest antiseizure medication is levetiracetam (LEV). It might be
effective in various indications, not only related to convulsions. Central nervous system …

Introduction: Brivaracetam (BRV) is an antiseizure medication (ASM), which has been
approved as an adjunctive treatment in adults and pediatric patients aged four years and …