In the initiation or exacerbation of Alzheimer disease, the dissemination of oral
microorganisms into the brain tissue or the low‐level systemic inflammation have been …

The gut microbiome influences many host physiologies, spanning gastrointestinal function,
metabolism, immune homeostasis, neuroactivity, and behavior. Many microbial effects on …

The oral cavity, like other digestive or mucosal sites, contains a site-specific microbiome that
plays a significant role in maintaining health and homeostasis. Strictly speaking, the …

The cause of Alzheimer's disease (AD), and the pathophysiological mechanisms involved,
remain major unanswered questions in medical science. Oral bacteria, especially those …

Background: Pre-clinical evidence implicates oral bacteria in the pathogenesis of
Alzheimer's disease (AD), while clinical studies show diverse results. Objective: To …

Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by a
progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may …

Background Emerging evidence suggests that gut microbiota dysbiosis may play a critical
role in the development of lupus nephritis (LN). However, the specific characteristics of the …

It is widely recognized that periodontal disease is an inflammatory entity of infectious origin,
in which the immune activation of the host leads to the destruction of the supporting tissues …

Aim Necroptosis participates in the pathogenesis of many inflammatory diseases, including
periodontitis. Here, we aimed to investigate the role and mechanism of necroptosis inhibitors …

Neuroinflammation is a universal characteristic of brain aging and neurological disorders,
irrespective of the disease state. Glial inflammation mediates this signaling, through …