[HTML][HTML] Host responses to mucosal biofilms in the lung and gut

JC Domingue, JL Drewes, CA Merlo, F Housseau… - Mucosal …, 2020 - Elsevier
The impact of the human microbiome on health and disease is of utmost importance and has
been studied intensively in recent years. Microbes promote immune system development …

The lung microbiome in COPD and lung cancer: Exploring the potential of metal-based drugs

M O'Shaughnessy, O Sheils, AM Baird - International Journal of …, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) and lung cancer 17 are two of the most
prevalent and debilitating respiratory diseases worldwide, both associated with high …

Accelerated Lung Function Decline and Mucus–Microbe Evolution in Chronic Obstructive Pulmonary Disease

OW Meldrum, GC Donaldson, JK Narayana… - American Journal of …, 2024 - atsjournals.org
Rationale: Progressive lung function loss is recognized in chronic obstructive pulmonary
disease (COPD); however, no study concurrently evaluates how accelerated lung function …

Sonic hedgehog signaling is essential for pulmonary ionocyte specification in human and ferret Airway Epithelia

Q Cai, M Luo, Y Tang, M Yu, F Yuan… - American journal of …, 2023 - atsjournals.org
Pulmonary ionocytes express high levels of cystic fibrosis transmembrane conductance
regulator (CFTR), an anion channel that is critical for hydration of the airways and …

Advanced approaches to overcome biological barriers in respiratory and systemic routes of administration for enhanced nucleic acid delivery to the lung

G Kwak, D Lee, JS Suk - Expert Opinion on Drug Delivery, 2023 - Taylor & Francis
Introduction Numerous delivery strategies, primarily novel nucleic acid delivery carriers,
have been developed and explored to enable therapeutically relevant lung gene therapy …

The multifaceted roles of microRNAs in cystic fibrosis

FDE De Palma, V Raia, G Kroemer, MC Maiuri - Diagnostics, 2020 - mdpi.com
Cystic fibrosis (CF) is a lifelong disorder affecting 1 in 3500 live births worldwide. It is a
monogenetic autosomal recessive disease caused by loss-of-function mutations in the gene …

Genomic diversity and antimicrobial resistance of Prevotella species isolated from chronic lung disease airways

KA Webb, O Olagoke, T Baird, J Neill… - Microbial …, 2022 - microbiologyresearch.org
Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are characterized by
increasingly frequent acute pulmonary exacerbations that reduce life quality and length …

[HTML][HTML] Challenges and Opportunities in COPD Management in Latin America: A Review of Inhalation Therapies and Advanced Drug Delivery Systems

JS Izquierdo-Condoy, C Salazar-Santoliva… - Pharmaceutics, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide, particularly in low-and middle-income countries, where it poses a significant …

Chronic obstructive pulmonary disease and the modulation of CFTR by acute exposure to cigarette smoke

JW Hanrahan, A Abu-Arish, FH Wong… - … of Physiology-Cell …, 2022 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is a leading cause of death and cigarette
smoke is the main risk factor. Detecting its earliest stages and preventing a decline in lung …

[HTML][HTML] Important functions and molecular mechanisms of aquaporins family on respiratory diseases: potential translational values

J Li, D Yang, L Lin, L Yu, L Chen, K Lu, J Lan… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Aquaporins (AQPs) are a subgroup of small transmembrane transporters that are distributed
in various types of tissues, including the lung, kidney, heart and central nervous system. It is …