Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

Y Wu, K Chen, J Wang, M Chen, W Dai… - Journal of the American …, 2024 - ACS Publications
Polypeptides have the same or similar backbone structures as proteins and peptides,
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …

Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis

Y Wu, K Chen, J Wang, W Dai, H Yu, X Xie, M Chen… - Nature …, 2024 - nature.com
Synthetic polypeptides, also known as poly (α-amino acids), have the same polyamide
backbone structures as natural proteins and peptides. As an important class of biomaterials …

Superfast and Water‐Insensitive Polymerization on α‐Amino Acid N‐Carboxyanhydrides to Prepare Polypeptides Using Tetraalkylammonium Carboxylate as the …

Y Wu, K Chen, X Wu, L Liu, W Zhang… - Angewandte …, 2021 - Wiley Online Library
We design the tetraalkylammonium carboxylate‐initiated superfast polymerization on α‐
amino acid N‐carboxyanhydrides (NCA) for efficient synthesis of polypeptides …

pH‐and temperature‐responsive hydrogels based on tertiary amine‐modified polypeptides for stimuli‐responsive drug delivery

Z Lin, J Ding, X Chen, C He - Chemistry–An Asian Journal, 2023 - Wiley Online Library
Abstract pH‐and temperature‐responsive hydrogels have attracted considerable attention
due to their responsiveness to dual physiologically‐relevant stimuli. In this study, we …

Organobase 1, 1, 3, 3-tetramethyl guanidine catalyzed rapid ring-opening polymerization of α-amino acid N-carboxyanhydrides adaptive to amine, alcohol and …

K Li, Z Li, Y Shen, X Fu, C Chen, Z Li - Polymer Chemistry, 2022 - pubs.rsc.org
The initiators for ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides
(NCA) to prepare polypeptides usually require high nucleophilicity. For initiators with lower …

Tertiary-butylbenzene functionalization as a strategy for β-sheet polypeptides

R Nisal, M Jayakannan - Biomacromolecules, 2022 - ACS Publications
β-Sheet forming polypeptides are one of the least explored synthetic systems due to their
uncontrolled precipitation in the ring-opening polymerization (ROP) synthetic methodology …

An inspection into multifarious ways to synthesize poly (amino acid) s

B Zheng, T Bai, X Tao, J Ling - Macromolecular Rapid …, 2021 - Wiley Online Library
Poly (α‐amino acid) s (PAAs) attract growing attention due to their essential role in the
application as biomaterials. To synthesize PAAs with desired structures and properties …

Facile synthesis of polypeptoids bearing bulky sidechains via urea accelerated ring-opening polymerization of α-amino acid N-substituted N-carboxyanhydrides

K Chen, Y Wu, X Wu, M Zhou, R Zhou, J Wang… - Polymer …, 2022 - pubs.rsc.org
Polypeptoids, as synthetic mimics of polypeptides, exhibit a variety of biological functions
and excellent proteolytic stability. Polypeptoids can be synthesized by the ring-opening …

Facile synthesis of imidazolium-based block copolypeptides with excellent antimicrobial activity

Z Shi, X Zhang, Z Yu, F Yang, H Liu, R Xue… - …, 2021 - ACS Publications
Antimicrobial polypeptides are promising mimics of antimicrobial peptides (AMPs) with low
risks of antimicrobial resistance (AMR). Polypeptides with facile and efficient production …

Well-defined star (co) polypeptides via a fast, efficient, and metal-free strategy

Y Zhao, W Zhao, Y Lv, L Jin, Y Ni… - International Journal of …, 2024 - Elsevier
Polypeptides, especially star polypeptides, as a unique kind of biological macromolecules
have broad applications in biomedical fields such as drug release, gene delivery, tissue …