The challenge of delivering therapeutic aerosols to asthma patients

F Lavorini - International Scholarly Research Notices, 2013 - Wiley Online Library
The number of people with asthma continues to grow around the world, and asthma remains
a poorly controlled disease despite the availability of management guidelines and highly …

Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants.

JH Wildhaber, SG Devadason, E Eber, MJ Hayden… - Thorax, 1996 - thorax.bmj.com
BACKGROUND: A study was undertaken to determine the influences of electrostatic charge,
flow, delay, and multiple actuations on the in vitro delivery of salbutamol generated by a …

Pressurized metered dose inhalers and add-on devices

C Terzano - Pulmonary pharmacology & therapeutics, 2001 - Elsevier
Metered dose inhalers (MDIs) which have a valve holding chamber plus a mouthpiece or
mask have, in recent years, markedly improved the ease, speed and reliability of aerosol …

Factors affecting total and" respirable" dose delivered by a salbutamol metered dose inhaler.

ML Everard, SG Devadason, QA Summers… - Thorax, 1995 - thorax.bmj.com
BACKGROUND--Many factors contribute to the high variability of doses delivered to the
lungs of patients using metered dose inhalers (MDIs). Relatively little attention has been …

Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease

R Pisi, M Aiello, A Zanini, P Tzani… - … journal of chronic …, 2015 - Taylor & Francis
Background We investigated whether a relationship between small airways dysfunction and
bronchodilator responsiveness exists in patients with chronic obstructive pulmonary disease …

[HTML][HTML] The course of inhalation profiles during an exacerbation of obstructive lung disease

MEAC Broeders, J Molema, WCJ Hop, NA Vermue… - Respiratory …, 2004 - Elsevier
Background: Acute exacerbations of asthma and chronic obstructive pulmonary disease
(COPD) are associated with increased airflow limitation, hyperinflation and respiratory …

Effect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device.

DJ Clark, BJ Lipworth - Thorax, 1996 - thorax.bmj.com
BACKGROUND: The aim of this study was to extend previous in vitro observations regarding
the effects of multiple actuations of aerosols into spacer devices, delayed inhalation, and …

Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers

J Svedmyr, E Nyberg, P Thunqvist… - Acta …, 1999 - Wiley Online Library
The aim of this study was to investigate whether budesonide, for 10 d, administered at the
first sign of an upper respiratory tract infection, could reduce asthma symptoms in 1‐3‐y‐old …

[引用][C] Problems with inhaler use: a call for improved clinician and patient education

JB Fink, BK Rubin - Respiratory care, 2005 - Respiratory Care

[引用][C] Aerosol delivery devices in the treatment of asthma

DR Hess - Respiratory care, 2008 - Respiratory Care