Engineering the next generation of cell-based therapeutics

CJ Bashor, IB Hilton, H Bandukwala… - Nature Reviews Drug …, 2022 - nature.com
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

Microneedle system for tissue engineering and regenerative medicine

Y Zhang, Y Xu, H Kong, J Zhang, HF Chan… - …, 2023 - Wiley Online Library
Global increasing demand for high life quality and length facilitates the development of
tissue engineering and regenerative medicine, which apply multidisciplinary theories and …

Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation

Y Yang, R Luo, S Chao, J Xue, D Jiang… - Nature …, 2022 - nature.com
Epidermal growth factor is an excellent drug for promoting wound healing; however, its
conventional administration strategies are associated with pharmacodynamic challenges …

[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

S Lyu, Z Dong, X Xu, HP Bei, HY Yuen, CWJ Cheung… - Bioactive materials, 2023 - Elsevier
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its
non-invasiveness, painless and simple administration, controllable drug delivery, and …

[HTML][HTML] Advanced nanocarrier-and microneedle-based transdermal drug delivery strategies for skin diseases treatment

F Qu, R Geng, Y Liu, J Zhu - Theranostics, 2022 - ncbi.nlm.nih.gov
Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a
global burden and affecting the world economy. Skin diseases severely impact the patients' …

Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway

Q Zhang, L Shi, H He, X Liu, Y Huang, D Xu, M Yao… - ACS …, 2022 - ACS Publications
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …

Microneedles in drug delivery: progress and challenges

M Avcil, A Çelik - Micromachines, 2021 - mdpi.com
In recent years, an innovative transdermal delivery technology has attracted great interest for
its ability to distribute therapeutics and cosmeceuticals for several applications, including …

Implantable electronic medicine enabled by bioresorbable microneedles for wireless electrotherapy and drug delivery

Y Huang, H Li, T Hu, J Li, CK Yiu, J Zhou, J Li… - Nano Letters, 2022 - ACS Publications
A combined treatment using medication and electrostimulation increases its effectiveness in
comparison with one treatment alone. However, the organic integration of two strategies in …

Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

J Xu, H Cai, Z Wu, X Li, C Tian, Z Ao, VC Niu… - Nature …, 2023 - nature.com
Transdermal drug delivery provides convenient and pain-free self-administration for
personalized therapy. However, challenges remain in treating acute diseases mainly due to …

Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …