Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease that, in the
most severe cases and when left untreated, leads to death within the first two years of life …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

The polyphenolic alcohol resveratrol has demonstrated promising activities for the
prevention and treatment of cancer. Different modes of action have been described for …

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its
potential therapeutic use in the treatment of many diseases, including cancer, diabetes …

In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to
understand the structural requirements for HDAC inhibition activity. Several modifications …

It is thought that germ cells and preimplantation embryos during development are most
susceptible to endogenous and exogenous environmental factors because the epigenome …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …

Background Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the
survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in …

Glycerol is a co-solvent for water extraction that has been shown to be highly effective for
obtaining polyphenol extracts under atmospheric conditions. However, its efficacy under …

Aging is one of the world's greatest concerns, requiring urgent, effective, large-scale
interventions to decrease the number of late-life chronic diseases and improve human …