Metastatic breast cancer is a life‐threatening stage of cancer and is the leading cause of
death in advanced breast cancer patients. Estrogen signaling and the estrogen receptor …

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

The potential “health benefits” of dietary polyphenols have been ascribed to their direct
antioxidant activity and their impact on the regulation of cell and tissue redox balance …

The functions of estrogens are relatively well known, however the molecular mechanism of
their action is not clear. The classical pathway of estrogen action is dependent on ERα and …

The human programmed cell death 4 (PDCD4) gene was mapped at chromosome 10q24
and encodes the PDCD4 protein comprised of 469 amino acids. PDCD4 inhibits protein …

The participation of extranuclear steroid receptor signaling in organ physiology and the
impact for pathobiology has increasingly been demonstrated. Important functions of …

An essential regulator of gene transcription, nuclear receptor liver receptor homologue 1
(LRH-1) controls cell differentiation in the developing pancreas and maintains cholesterol …

Tumor metastasis is the leading cause of death among breast cancer patients. PELP1
(proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is …

Cancer is the disease with highest public health impact in developed countries. Particularly,
breast cancer has the highest incidence in women worldwide and the fifth highest mortality …

Despite important progress in adjuvant and neoadjuvant therapies, metastatic disease often
develops in breast cancer patients and remains the leading cause of their deaths. For …