A hyperphosphorylated guanosine nucleotide,(p) ppGpp, was initially identified as the
effector molecule responsible for the stringent response in Escherichia coli. However, a …

The stringent response is a conserved bacterial stress response mechanism that allows
bacteria to respond to nutritional challenges. It is mediated by the alarmones pppGpp and …

Bacteria respond to nutritional stresses by producing an intracellular alarmone, guanosine
5′‐(tri) diphosphate, 3′‐diphosphate [(p) ppGpp], which triggers the stringent response …

CsrA protein regulates important cellular processes by binding to target mRNAs and altering
their translation and/or stability. In Escherichia coli, CsrA binds to sRNAs, CsrB and CsrC …

Being exposed to various kinds of stress in their natural environments, bacteria usually grow
slowly or even have to use their limited resources entirely for maintenance and stress …

How cells establish, maintain, and modulate size has always been an area of great interest
and fascination. Until recently, technical limitations curtailed our ability to understand the …

Microbial culturability can be ephemeral. Cells are not merely either dead or alive but can
adopt physiological states in which they appear to be (transiently) non-culturable under …

In their stressful natural environments, bacteria often are in stationary phase and use their
limited resources for maintenance and stress survival. Underlying this activity is the general …

The stringent response is a universal adaptive mechanism to protect bacteria from nutritional
and environmental stresses. The role of the stringent response during lipid starvation has …

It now seems clear that starvation adaptation is important for cells to initiate long-term
survival under conditions of not only nutrient depletion but to develop resistance to other …