Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

W Liu, R Gust - Coordination Chemistry Reviews, 2016 - Elsevier
The clinical success of platinum-based chemotherapeutic agents was of enormous impact
on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti …

Nanotechnology for angiogenesis: opportunities and challenges

S Kargozar, F Baino, S Hamzehlou… - Chemical Society …, 2020 - pubs.rsc.org
Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

Molecular mechanisms and clinical implications of the gold drug auranofin

S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

W Liu, R Gust - Chemical Society Reviews, 2013 - pubs.rsc.org
The discovery of cisplatin's antitumor activity in 1969 prompted the search for novel metal-
containing complexes as potential anticancer drugs. Among these novel complexes, metal N …

The gold complex auranofin: new perspectives for cancer therapy

FH Abdalbari, CM Telleria - Discover Oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

A general mechanism for intracellular toxicity of metal-containing nanoparticles

S Sabella, RP Carney, V Brunetti, MA Malvindi… - Nanoscale, 2014 - pubs.rsc.org
The assessment of the risks exerted by nanoparticles is a key challenge for academic,
industrial, and regulatory communities worldwide. Experimental evidence points towards …

Metal complexes, an untapped source of antibiotic potential?

A Frei - Antibiotics, 2020 - mdpi.com
With the widespread rise of antimicrobial resistance, most traditional sources for new drug
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …

Stable cyclic carbenes and related species beyond diaminocarbenes

M Melaimi, M Soleilhavoup… - Angewandte Chemie …, 2010 - Wiley Online Library
The success of homogeneous catalysis can be attributed largely to the development of a
diverse range of ligand frameworks that have been used to tune the behavior of various …