Heterogeneity of BCSCs contributes to the metastatic organotropism of breast cancer

C Wang, K Xu, R Wang, X Han, J Tang… - Journal of Experimental & …, 2021 - Springer
Breast cancer is one of the most-common female malignancies with a high risk of relapse
and distant metastasis. The distant metastasis of breast cancer exhibits organotropism …

Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling

KG Foley, M Adli, JJ Kim - Proceedings of the National Academy of …, 2024 - pnas.org
Significant racial disparities exist between Black and White patients with uterine serous
carcinoma (USC). While the reasons for these disparities are unclear, several studies have …

Signaling networks controlling ID and E protein activity in T cell differentiation and function

SM Hwang, SH Im, D Rudra - Frontiers in Immunology, 2022 - frontiersin.org
E and inhibitor of DNA binding (ID) proteins are involved in various cellular developmental
processes and effector activities in T cells. Recent findings indicate that E and ID proteins …

A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer

M Kim, M Singh, BK Lee, M Hibbs, K Richardson… - Oncogenesis, 2022 - nature.com
The MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in
breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease …

Single-Cell RNA Sequencing Reveals Molecular Features of Heterogeneity in the Murine Retinal Pigment Epithelium

RS Pandey, MP Krebs, MT Bolisetty… - International Journal of …, 2022 - mdpi.com
Transcriptomic analysis of the mammalian retinal pigment epithelium (RPE) aims to identify
cellular networks that influence ocular development, maintenance, function, and disease …

Apolipoprotein C1 (APOC1): A novel diagnostic and prognostic biomarker for cervical cancer

X Shi, J Wang, S Dai, L Qin, J Zhou… - OncoTargets and …, 2020 - Taylor & Francis
Background Previous reports showed that APOC1 was associated with several cancers but
the function of APOC1 in cervical cancer was unknown. This study aimed to investigate the …

Id proteins promote a cancer stem cell phenotype in mouse models of triple negative breast cancer via negative regulation of Robo1

WS Teo, H Holliday, N Karthikeyan… - Frontiers in Cell and …, 2020 - frontiersin.org
Breast cancers display phenotypic and functional heterogeneity and several lines of
evidence support the existence of cancer stem cells (CSCs) in certain breast cancers, a …

How vitamin E and its derivatives regulate tumour cells via the MAPK signalling pathway?'

ZQ Yu, LM Wang, WX Yang - Gene, 2022 - Elsevier
In tumour cells, vitamin E and its derivatives play a critical role in the regulation of multiple
signalling pathways through their oxidative and nonoxidative functions. To date, there are 8 …

Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases

Y Wen, Y Zheng, S Hua, T Li, X Bi, Q Lu, M Li… - Current Allergy and …, 2025 - Springer
Purpose of review Bone morphogenetic protein 2 (BMP2) belongs to the transforming
growth factor-β (TGF-β) superfamily and plays an important role in regulating embryonic …

[HTML][HTML] Silibinin is a suppressor of the metastasis-promoting transcription factor ID3

S Verdura, JA Encinar, A Gratchev, À Llop-Hernández… - Phytomedicine, 2024 - Elsevier
Background ID3 (inhibitor of DNA binding/differentiation-3) is a transcription factor that
enables metastasis by promoting stem cell-like properties in endothelial and tumor cells …