Dissecting the role of protein phosphorylation: a chemical biology toolbox

T Bilbrough, E Piemontese, O Seitz - Chemical Society Reviews, 2022 - pubs.rsc.org
Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …

D‐peptide and d‐protein technology: recent advances, challenges, and opportunities

AJ Lander, Y Jin, LYP Luk - ChemBioChem, 2023 - Wiley Online Library
Total chemical protein synthesis provides access to entire D‐protein enantiomers enabling
unique applications in molecular biology, structural biology, and bioactive compound …

Deciphering the Role of the Ser‐Phosphorylation Pattern on the DNA‐Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis

RV Nithun, YM Yao, X Lin, S Habiballah… - Angewandte Chemie …, 2023 - Wiley Online Library
The chemical synthesis of site‐specifically modified transcription factors (TFs) is a powerful
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …

Multiphosphorylation-Dependent Recognition of Anti-pS2 Antibodies against RNA Polymerase II C-Terminal Domain Revealed by Chemical Synthesis

E Piemontese, A Herfort… - Journal of the …, 2024 - ACS Publications
Phosphorylation is a major constituent of the CTD code, which describes the set of post-
translational modifications on 52 repeats of a YSPTSPS consensus heptad that orchestrates …

Folding and stability of ankyrin repeats control biological protein function

A Kumar, J Balbach - Biomolecules, 2021 - mdpi.com
Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins
are involved in protein-protein interaction in order to activate or suppress biological …

CIP/KIP and INK4 families as hostages of oncogenic signaling

L Csergeová, D Krbušek, R Janoštiak - Cell Division, 2024 - Springer
Abstract CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-
established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK …

Kontextově závislé role inhibitorů cyklin-dependentních kináz (CDKi) u rakoviny

Š Doležalová - 2024 - dspace.cuni.cz
Progrese buněčného cyklu je složitě regulována mnoha proteiny. Mezi těmito proteiny hrají
klíčovou roli inhibitory cyklin-dependentních kináz (CKI), které jsou tradičně spojované s …

D-protein and D-peptide technology in applied research

A Lander - 2022 - orca.cardiff.ac.uk
Chemical protein synthesis provides access to entire D-protein enantiomers, with unique
utility in applied research. Firstly, proteins may be crystallized from a racemic mixture of L …