[HTML][HTML] The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

B Pedre, U Barayeu, D Ezeriņa, TP Dick - Pharmacology & therapeutics, 2021 - Elsevier
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …

Oxidative stress and metabolism: a mechanistic insight for glyphosate toxicology

X Wang, Q Lu, J Guo, I Ares, M Martínez… - Annual review of …, 2022 - annualreviews.org
Glyphosate (GLYP) is a widely used pesticide; it is considered to be a safe herbicide for
animals and humans because it targets 5-enolpyruvylshikimate-3-phosphate synthase …

[HTML][HTML] Mapping the key characteristics of carcinogens for glyphosate and its formulations: a systematic review

I Rana, PK Nguyen, G Rigutto, A Louie, J Lee… - Chemosphere, 2023 - Elsevier
Glyphosate was classified as a probable human carcinogen by the International Agency for
Research on Cancer (IARC) partially due to strong mechanistic evidence in 2015. Since …

A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

CJ Portier - Environmental Health, 2020 - Springer
Since the introduction of glyphosate-tolerant genetically-modified plants, the global use of
glyphosate has increased dramatically making it the most widely used pesticide on the …

Mutagenicity, hepatotoxicity, and neurotoxicity of glyphosate and fipronil commercial formulations in Amazon turtles neonates (Podocnemis expansa)

J dos Santos Mendonça, JCN de Almeida… - Science of The Total …, 2023 - Elsevier
Pesticides are considered one of the main causes of the population decline of reptiles
worldwide, with freshwater turtles being particularly susceptible to aquatic contamination. In …

[HTML][HTML] The association between urinary glyphosate and aminomethyl phosphonic acid with biomarkers of oxidative stress among pregnant women in the PROTECT …

JL Eaton, AL Cathey, JA Fernandez, DJ Watkins… - Ecotoxicology and …, 2022 - Elsevier
Background Glyphosate is a widely used herbicide in global agriculture. Glyphosate and its
primary environmental degradate, aminomethyl phosphonic acid (AMPA), have been shown …

Glyphosate based-herbicide disrupts energy metabolism and activates inflammatory response through oxidative stress in mice liver

L Qi, YM Dong, H Chao, P Zhao, SL Ma, G Li - Chemosphere, 2023 - Elsevier
Glyphosate, the most widely used herbicide worldwide, has been reported to cause
hepatotoxicity. However, these systematic mechanisms remain poorly understood. Here, we …

A Mixture of Endocrine Disruptors and the Pesticide Roundup® Induce Oxidative Stress in Rabbit Liver When Administered under the Long-Term Low-Dose Regimen …

P Vardakas, AS Veskoukis, D Rossiou, C Gournikis… - Toxics, 2022 - mdpi.com
Humans are exposed to xenobiotic mixtures daily through the long-term, low-dose regimen.
Investigations designed to simulate this exposure profile approach the real-life risk …

[HTML][HTML] Perinatal exposure to a glyphosate pesticide formulation induces offspring liver damage

CEH Rieg, D Cattani, NF Naspolini, VH Cenci… - Toxicology and Applied …, 2022 - Elsevier
The present study investigated the effects of perinatal exposure to glyphosate-based
herbicide (GBH) in offspring's liver. Pregnant Wistar rats were exposed to GBH (70 mg …

Glyphosate and AMPA exposure in relation to markers of biological aging in an adult population-based study

C Cosemans, N Van Larebeke, BG Janssen… - International Journal of …, 2022 - Elsevier
Abstract Background/Aim Glyphosate, a broad-spectrum herbicide, and its main metabolite
aminomethylphosphonic acid (AMPA) are persistent in the environment. Studies showed …