Abstract The Enzyme Function Initiative, an NIH/NIGMS-supported Large-Scale
Collaborative Project (EFI; U54GM093342; http://enzymefunction. org/), is focused on …

The exponentially increasing number of protein and nucleic acid sequences provides
opportunities to discover novel enzymes, metabolic pathways, and metabolites/natural …

Bacteria of the SAR202 clade, within the phylum Chloroflexota, are ubiquitously distributed
in the ocean but have not yet been cultivated in the lab. It has been proposed that ancient …

Cellular senescence affects many physiological and pathological processes and is
characterized by durable cell cycle arrest, an inflammatory secretory phenotype and …

The rate at which genome sequencing data is accruing demands enhanced methods for
functional annotation and metabolism discovery. Solute binding proteins (SBPs) facilitate the …

The acI lineage of the phylum Actinobacteria is the most abundant bacterial group in most
freshwater lakes. However, due to difficulties in laboratory cultivation, only two mixed …

Engineering of the yeast Saccharomyces cerevisiae towards efficient d-xylose assimilation
has been a major focus over the last decades since d-xylose is the second most abundant …

The functions of most proteins are yet to be determined. The function of an enzyme is often
defined by its interacting partners, including its substrate and product, and its role in larger …

Whilst∼ 93% of domain superfamilies appear to be relatively structurally and functionally
conserved based on the available data from the CATH-Gene3D domain classification …

We describe here the identification and characterization of two novel enzymes belonging to
the IlvD/EDD protein family, the D-xylonate dehydratase from Caulobacter crescentus, Cc …