Recent advances in the chemical composition and biological activities of propolis

O Belmehdi, N El Menyiy, A Bouyahya… - Food Reviews …, 2023 - Taylor & Francis
Propolis is a resinous substance from beehive produced by the combination of plants and
bee secretions. For a long time, this substance has gotten high attention in traditional and …

Cell Cycle, Telomeres, and Telomerase in Leishmania spp.: What Do We Know So Far?

LHC Assis, D Andrade-Silva, ME Shiburah… - Cells, 2021 - mdpi.com
Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting
different degrees of manifestations severity. It is caused by the transmission of more than 20 …

[HTML][HTML] Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13

D Jiang, X Sun, S Wang, H Man - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Ischemic stroke represents a major cause of adult physical disability, which is triggered by
cerebral artery occlusion induced blood flow blockage. MiR-874-3p has been reported to be …

Whole cell reconstructions of Leishmania mexicana through the cell cycle

M Hair, R Yanase, F Moreira-Leite, RJ Wheeler… - Plos …, 2024 - journals.plos.org
The unicellular parasite Leishmania has a precisely defined cell architecture that is inherited
by each subsequent generation, requiring a highly coordinated pattern of duplication and …

Leishmanicidal activity of isoselenocyanate derivatives

C Fernández-Rubio, E Larrea… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Conventional chemotherapy against leishmaniasis includes agents exhibiting considerable
toxicity. In addition, reports of drug resistance are not uncommon. Thus, safe and effective …

Differences in the detection of BrdU/EdU incorporation assays alter the calculation for G1, S, and G2 phases of the cell cycle in trypanosomatids

MS da Silva, PAM Muñoz, HA Armelin… - Journal of Eukaryotic …, 2017 - Wiley Online Library
Trypanosomatids are the etiologic agents of various infectious diseases in humans. They
diverged early during eukaryotic evolution and have attracted attention as peculiar models …

[HTML][HTML] Consequences of acute oxidative stress in Leishmania amazonensis: From telomere shortening to the selection of the fittest parasites

MS da Silva, M Segatto, RS Pavani… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Leishmaniasis is a spectrum of diseases caused by parasites of the genus Leishmania that
affects millions of people around the world. During infection, the parasites use different …

MiR-3188 inhibits non-small cell lung cancer cell proliferation through FOXO1-mediated mTOR-p-PI3K/AKT-c-JUN signaling pathway

C Wang, E Liu, W Li, J Cui, T Li - Frontiers in pharmacology, 2018 - frontiersin.org
This study investigated the role of miR-3188 on the proliferation of non-small cell lung
cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell …

Panacea within a Pandora's box: the antiparasitic effects of phospholipases A2 (PLA2s) from snake venoms

SC Teixeira, MS da Silva, AAS Gomes, NS Moretti… - Trends in …, 2022 - cell.com
Parasitic diseases affect millions of individuals worldwide, mainly in low-income regions.
There is no cure for most of these diseases, and the treatment relies on drugs that have side …

Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration

MS da Silva, GR Cayres-Silva, MO Vitarelli… - Scientific Reports, 2019 - nature.com
The co-synthesis of DNA and RNA potentially generates conflicts between replication and
transcription, which can lead to genomic instability. In trypanosomatids, eukaryotic parasites …