Alternative animal models of aging research

S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Neoteny, prolongation of youth: from naked mole rats to “naked apes”(humans)

VP Skulachev, S Holtze, MY Vyssokikh… - Physiological …, 2017 - journals.physiology.org
It has been suggested that highly social mammals, such as naked mole rats and humans,
are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot …

Transcriptome mining extends the host range of the Flaviviridae to non-bilaterians

JCO Mifsud, VA Costa, ME Petrone… - Virus …, 2023 - academic.oup.com
The flavivirids (family Flaviviridae) are a group of positive-sense RNA viruses that include
well-documented agents of human disease. Despite their importance and ubiquity, the …

From humans to hydra: patterns of cancer across the tree of life

TAF Albuquerque, L Drummond do Val… - Biological …, 2018 - Wiley Online Library
Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …

Social evolution in African mole-rats–a comparative overview

CG Faulkes, NC Bennett - The Extraordinary Biology of the Naked Mole …, 2021 - Springer
The African mole-rat superfamily are a unique group of subterranean rodents that are
remarkable for their adaptations to a subterranean lifestyle and their range in sociality …

Specialized mechanoreceptor systems in rodent glabrous skin

J Walcher, J Ojeda‐Alonso, J Haseleu… - The Journal of …, 2018 - Wiley Online Library
Key points An ex vivo preparation was developed to record from single sensory fibres
innervating the glabrous skin of the mouse forepaw. The density of mechanoreceptor …

Rapid molecular evolution of pain insensitivity in multiple African rodents

O Eigenbrod, KY Debus, J Reznick, NC Bennett… - Science, 2019 - science.org
Noxious substances, called algogens, cause pain and are used as defensive weapons by
plants and stinging insects. We identified four previously unknown instances of algogen …

Dietary diversification and specialization in neotropical bats facilitated by early molecular evolution

JHT Potter, KTJ Davies, LR Yohe… - Molecular Biology …, 2021 - academic.oup.com
Dietary adaptation is a major feature of phenotypic and ecological diversification, yet the
genetic basis of dietary shifts is poorly understood. Among mammals, Neotropical leaf …

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan

A Sahm, M Bens, K Szafranski, S Holtze, M Groth… - PLoS …, 2018 - journals.plos.org
The genetics of lifespan determination is poorly understood. Most research has been done
on short-lived animals and it is unclear if these insights can be transferred to long-lived …

PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes

A Sahm, M Bens, M Platzer… - Nucleic Acids …, 2017 - academic.oup.com
Many comparative genomics studies aim to find the genetic basis of species-specific
phenotypic traits. A prevailing strategy is to search genome-wide for genes that evolved …