Despite the success of the WHO-led smallpox eradication programme a quarter of a century
ago, there remains considerable fear that variola virus, or other related pathogenic …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

Human monkeypox was first recognized outside Africa in 2003 during an outbreak in the
USA that was traced to imported monkeypox virus (MPXV)-infected West African rodents …

Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor
necrosis factor family mediate this process. They either assist persistent viral infection or …

Murine gammaherpesvirus 68 (gammaHV68) infects mice, thus providing a tractable small-
animal model for analysis of the acute and chronic pathogenesis of gammaherpesviruses …

To identify novel antiapoptotic proteins encoded by DNA viruses, we searched viral
genomes for proteins that might interfere with Fas and TNFR1 apoptotic signaling pathways …

Abstract Murine gammaherpesvirus 68 (MHV-68) is a naturally occurring herpesvirus of wild
rodents and is genetically related to human herpesvirus 8 and Epstein-Barr virus. The ability …

The vaccinia virus (VV) strain Western Reserve B13R gene encodes a 38.5 kDa intracellular
polypeptide that is non-essential for virus replication in vitro and does not affect virus …

Apoptosis, or programmed cell death, is the physiological process whereby individual cells
are deliberately eliminated to achieve homeostasis and proper metazoan development …

The vaccinia virus E3L gene codes for double-stranded RNA (dsRNA) binding proteins
which can prevent activation of the dsRNA-dependent, interferon-induced protein kinase …