Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

Background Jaundice is a common symptom of inherited or acquired liver diseases or a
manifestation of diseases involving red blood cell metabolism. Recent progress has …

NAD+ and glutathione precursors are currently used as metabolic modulators for improving
the metabolic conditions associated with various human diseases, including non-alcoholic …

Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades,
yet the molecular mechanisms at the core of this damage remain largely unknown …

Introduction: The in vivo fate and effectiveness of a drug depends highly on its absorption,
distribution, metabolism, excretion and toxicity (ADME-Tox). Organic anion transporting …

Evaluation of patients with jaundice starts with a careful history and physical examination,
followed by directed imaging of the biliary tree and liver. Although jaundice is generally …

Despite a century of research, bilirubin metabolism and the transport mechanisms
responsible for homeostasis of bilirubin in serum remain controversial. Emerging evidence …

The liver plays a prominent role in maintenance of homeostasis and is the major organ for
xenobiotic metabolism, including pesticides. Conventional liver function tests are widely …

Nonintegrative AAV-mediated gene therapy in the liver is effective in adult patients but faces
limitations in pediatric settings because of episomal DNA loss during hepatocyte …

Hyperbilirubinemia (jaundice) is caused by raised levels of unconjugated bilirubin in the
blood. When severe, susceptible brain regions including the cerebellum and auditory …