Cell migration is dependent on the dynamic formation and disassembly of actin filament–
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …

There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are
poised to transduce signals emanating from the cell surface. Cell membranes provide the …

The affinity and selectivity of small molecules for proteins drive drug discovery and
development. We report a fluorescent probe cellular binding assay (FPCBA) for …

Few kinases have been studied as extensively as protein kinase C (PKC), particularly in the
context of cancer. As major cellular targets for the phorbol ester tumor promoters and …

The spatial and temporal regulation of lipid molecules in cell membranes is a hallmark of
cellular signaling and membrane trafficking events. Lipid-mediated targeting provides for …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

C1 domains are small zinc-binding structural units of approximately 50 amino acid residues,
originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. Although …

Abstract Alzheimer's disease (AD), the most common cause of dementia, is an irreversible
and progressive neurodegenerative disorder. It affects predominantly brain areas that are …

Invadopodia formation is regulated by Rho GTPases. However, the molecular mechanisms
that control Rho GTPase signaling at invadopodia remain poorly understood. Here, we have …