New Insights into Butyrylcholinesterase: Pharmaceutical Applications, Selective Inhibitors and Multitarget-Directed Ligands
T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
Hybrid/Chimera Drugs-Part 1-Drug Hybrids Affecting Diseases of the Central Nervous System
A Nudelman - Current Medicinal Chemistry, 2024 - benthamdirect.com
This review, focused on hybrid drugs, is the third in a series of reviews, where the first two
reviews dealt with a) dimeric drugs, b) mutual prodrugs–codrugs. The compounds …
reviews dealt with a) dimeric drugs, b) mutual prodrugs–codrugs. The compounds …
Naringenin, Hesperidin and Quercetin Ameliorate Radiation‐Induced Damage In Rats: In Vivo And In Silico Evaluations
In this study, we sought to determine how well naringenin, hesperidin, and quercetin
prevented damage brought on by radiotherapy. During the investigation, 48 adult female …
prevented damage brought on by radiotherapy. During the investigation, 48 adult female …
Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors
Ö Soylu-Eter, N Özsoy, N Karalı - Future Medicinal Chemistry, 2024 - Taylor & Francis
Background: In Alzheimer's disease, butyrylcholinesterase (BuChE) activity gradually
increases, while acetylcholinesterase (AChE) activity decreases or remains unchanged …
increases, while acetylcholinesterase (AChE) activity decreases or remains unchanged …
Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors
KN Alcorn, IA Oberhauser, MD Politeski… - Journal of Enzyme …, 2024 - Taylor & Francis
Two series of N-alkyl isatins and N-alkyl indoles varying in size of the alkyl group were
synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and …
synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and …
Synthesis and Potential Dual Inhibitory Activity Against Acetylcholinesterase and Butyrylcholinesterase of Galactose‐Conjugated Isatin β‐Thiosemicarbazones
ND Thanh, NTK Giang, VN Toan, HTK Van… - …, 2023 - Wiley Online Library
A series of different isatin‐thiosemicarbazones 4 a–4 t derived from corresponding
substituted isatins and N‐(2, 3, 4, 6‐tetra‐O‐acetyl‐β‐d‐galactopyranosyl) …
substituted isatins and N‐(2, 3, 4, 6‐tetra‐O‐acetyl‐β‐d‐galactopyranosyl) …