Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Natural products as platforms to overcome antibiotic resistance

SE Rossiter, MH Fletcher, WM Wuest - Chemical reviews, 2017 - ACS Publications
Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

Enzymatic carbon–sulfur bond formation in natural product biosynthesis

KL Dunbar, DH Scharf, A Litomska… - Chemical …, 2017 - ACS Publications
Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Staphylococcus aureus pathogenesis in diverse host environments

D Balasubramanian, L Harper, B Shopsin… - Pathogens and …, 2017 - academic.oup.com
Staphylococcus aureus is an eminent human pathogen that can colonize the human host
and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide …

Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System

L Tan, SR Li, B Jiang, XM Hu, S Li - Frontiers in microbiology, 2018 - frontiersin.org
Staphylococcus aureus can cause numerous different diseases, which has been attributed
to its large repertoire of virulence factors, many of which are under the control of the …

[HTML][HTML] Two-component systems of S. aureus: signaling and sensing mechanisms

L Bleul, P Francois, C Wolz - Genes, 2022 - mdpi.com
Genes | Free Full-Text | Two-Component Systems of S. aureus: Signaling and Sensing Mechanisms
Next Article in Journal Genome-Wide Identification, Primary Functional Characterization of the …

Enzyme-responsive microneedle patch for bacterial infection and accelerated healing of diabetic wounds

S Wu, B Qin, X Tang, T Cui, S Yin, H Dong, Y Liu… - Chemical Engineering …, 2023 - Elsevier
Chronic diabetic wounds are caused by an array of pathologies. Pathogenic bacteria such
as S. aureus can easily invade hosts with deficient immunity. In this study, we developed a …

Thinking outside the box—novel antibacterials to tackle the resistance crisis

M Lakemeyer, W Zhao, FA Mandl… - Angewandte Chemie …, 2018 - Wiley Online Library
The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Research progress of bacterial quorum sensing receptors: Classification, structure, function and characteristics

L Yi, X Dong, D Grenier, K Wang, Y Wang - Science of the Total …, 2021 - Elsevier
The microbial community is an important part of the natural ecosystem, and the quorum
sensing system is a momentous communication tool for the microbial community to connect …

Contribution of quorum sensing to virulence and antibiotic resistance in zoonotic bacteria

Q Fan, J Zuo, H Wang, D Grenier, L Yi, Y Wang - Biotechnology advances, 2022 - Elsevier
Quorum sensing (QS), which is a key part of cell/cell communication, is widely distributed in
microorganisms, especially in bacteria. Bacteria can produce and detect the presence of QS …