Targeting epigenetics: a novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Exosome-Based Drug Delivery: Translation from Bench to Clinic

HB Koh, HJ Kim, SW Kang, TH Yoo - Pharmaceutics, 2023 - mdpi.com
Exosome-based drug delivery is emerging as a promising field with the potential to
revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles …

Anti-amyloid therapies for Alzheimer's disease and the amyloid cascade hypothesis

E Fedele - International journal of molecular sciences, 2023 - mdpi.com
Over the past 30 years, the majority of (pre) clinical efforts to find an effective therapy for
Alzheimer's disease (AD) focused on clearing the β-amyloid peptide (Aβ) from the brain …

Effects of DHA on cognitive dysfunction in aging and Alzheimer's disease: The mediating roles of ApoE

X Zhang, T Yuan, X Chen, X Liu, J Hu, Z Liu - Progress in Lipid Research, 2023 - Elsevier
The prevalence of Alzheimer's disease (AD) continues to rise due to the increasing aging
population. Among the various genetic factors associated with AD, apolipoprotein E (ApoE) …

Alzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches

A Gholami - Neuroscience Letters, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurological disorder that affects the central
nervous system (CNS), leading to memory and cognitive decline. In AD, the brain …

Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data

Y Sun, J Zhu, Y Yang, Z Zhang, H Zhong… - Translational …, 2023 - nature.com
Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is
critical to identify novel blood-based DNA methylation biomarkers to better understand the …

Advancing Alzheimer's therapeutics: exploring the impact of physical exercise in animal models and patients

J Andrade-Guerrero, P Rodríguez-Arellano… - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is the main neurodegenerative disorder characterized by several
pathophysiological features, including the misfolding of the tau protein and the amyloid beta …

[HTML][HTML] Biomarkers associated with the pathogenesis of Alzheimer's disease

H Wang, M Sun, W Li, X Liu, M Zhu… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …

Clathrin mediated endocytosis in Alzheimer's disease: cell type specific involvement in amyloid beta pathology

S Jaye, US Sandau, JA Saugstad - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
This review provides a comprehensive examination of the role of clathrin-mediated
endocytosis (CME) in Alzheimer's disease (AD) pathogenesis, emphasizing its impact …

Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration

J Kountouras, M Doulberis, A Papaefthymiou… - Medicina, 2023 - mdpi.com
Helicobacter pylori infection consists a high global burden affecting more than 50% of the
world's population. It is implicated, beyond substantiated local gastric pathologies, ie, peptic …