Designing antimicrobial peptides: form follows function

CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

A review on antimicrobial peptides databases and the computational tools

S Ramazi, N Mohammadi, A Allahverdi, E Khalili… - Database, 2022 - academic.oup.com
Abstract Antimicrobial Peptides (AMPs) have been considered as potential alternatives for
infection therapeutics since antibiotic resistance has been raised as a global problem. The …

α‐Defensins in human innate immunity

RI Lehrer, W Lu - Immunological reviews, 2012 - Wiley Online Library
Defensins are small, multifunctional cationic peptides. They typically contain six conserved
cysteines whose three intramolecular disulfides stabilize a largely β‐sheet structure. This …

β-Defensins: farming the microbiome for homeostasis and health

KG Meade, C O'Farrelly - Frontiers in Immunology, 2019 - frontiersin.org
Diverse commensal populations are now regarded as key to physiological homeostasis and
protection against disease. Although bacteria are the most abundant component of …

Machine learning and data science in soft materials engineering

AL Ferguson - Journal of Physics: Condensed Matter, 2017 - iopscience.iop.org
In many branches of materials science it is now routine to generate data sets of such large
size and dimensionality that conventional methods of analysis fail. Paradigms and tools from …

Mapping membrane activity in undiscovered peptide sequence space using machine learning

EY Lee, BM Fulan, GCL Wong… - Proceedings of the …, 2016 - National Acad Sciences
There are some∼ 1,100 known antimicrobial peptides (AMPs), which permeabilize
microbial membranes but have diverse sequences. Here, we develop a support vector …

Antifungal peptides as therapeutic agents

M Fernández de Ullivarri, S Arbulu… - Frontiers in Cellular …, 2020 - frontiersin.org
Fungi have been used since ancient times in food and beverage-making processes and,
more recently, have been harnessed for the production of antibiotics and in processes of …

In Silico Approach for Prediction of Antifungal Peptides

P Agrawal, S Bhalla, K Chaudhary, R Kumar… - Frontiers in …, 2018 - frontiersin.org
This paper describes in silico models developed using a wide range of peptide features for
predicting antifungal peptides (AFPs). Our analyses indicate that certain types of residue …

Avian host defense peptides

T Cuperus, M Coorens, A van Dijk… - Developmental & …, 2013 - Elsevier
Host defense peptides (HDPs) are important effector molecules of the innate immune system
of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and …

What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?

EY Lee, MW Lee, BM Fulan, AL Ferguson… - Interface …, 2017 - royalsocietypublishing.org
Antimicrobial peptides (AMPs) are a diverse class of well-studied membrane-permeating
peptides with important functions in innate host defense. In this short review, we provide a …