Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …

Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast,
worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1–7. Here, we review …

Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …

A progressive loss of neurons with age underlies a variety of debilitating neurological
disorders, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), yet …

In lower organisms, increased expression of the NAD-dependent deacetylase Sir2
augments lifespan. The mechanism through which this life extension is mediated remains …

Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the
nucleus that influences many cellular and organismal activities under both normal and …

The enzymes of the Sirtuin family of nicotinamide-adenine-dinucleotide-dependent protein
deacetylases are emerging key players in nuclear and cytosolic signaling, but also in …

Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast
longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are …

Polyphenols are the most abundant antioxidants in diet. Indeed, fruits, vegetables,
beverages (tea, wine, juices), plants, and some herbs are loaded with powerful antioxidant …