Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Rationale: The recent emergence of hydrogen sulfide (H2S) as a potent cardioprotective
signaling molecule necessitates the elucidation of its cytoprotective mechanisms. Objective …

Ischemia/reperfusion, which is characterized by deficient oxygen supply and subsequent
restoration of blood flow, can cause irreversible damages to tissue. Mechanisms contributing …

The leading cause of death in developed countries is cardiovascular disease, where
coronary heart disease is the main cause of death. Myocardial reperfusion is the most …

Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation
surgery. Understanding the mechanisms of liver ischemia reperfusion injury (IRI) and …

Despite nearly twenty years of research into the field of ischemic preconditioning, the actual
mechanism of protection remains unclear. However, much progress has been made in …

Cardiovascular disease is the most common cause of death among diabetic patients
worldwide. Hence, cardiovascular wellbeing in diabetic patients requires utmost importance …

The cardioprotection by ischemic preconditioning is lost in aged wild-type and in STAT3
(signal transducer and activator of transcription 3)-deficient mice. The aim of the present …

A standard ischemic preconditioning (IPC) stimulus of one or more brief episodes of non-
lethal myocardial ischemia and reperfusion elicits a bi-phasic pattern of cardioprotection …