There is a long-standing assumption that naive CD4+ and CD8+ T cells are largely
homogeneous populations despite the extraordinary diversity of their T cell receptors (TCR) …

Interferons (IFNs) are a family of proteins that are generated in response to viral infection
and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that …

Stem-like CD8+ T cells are regulated by T cell factor 1 (TCF1) and are considered requisite
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers.
Despite the successful application of immune checkpoint blockade in a range of human …

Upon antigenic stimulation, na ıve CD4+ T cells can give rise to phenotypically distinct
effector T helper cells and long-lived memory T cells. We computationally reconstructed the …

Sepsis, an amplified immune response to systemic infection, is characterized by a transient
cytokine storm followed by chronic immune dysfunction. Consequently, sepsis survivors are …

Immune diversification helps protect the host against a myriad of pathogens. CD8+ T cells
are essential adaptive immune cells that inhibit the spread of pathogens by inducing …

The advent of technologies that can characterize the phenotypes, functions and fates of
individual cells has revealed extensive and often unexpected levels of diversity between …

The proportions and phenotypes of immune cell subsets in peripheral blood undergo
continual and dramatic remodeling throughout the human life span, which complicates …

Previously, the presence of a blood-myenteric plexus barrier and its disruption was reported
in experimentally induced colitis via a macrophage-dependent process. The aim of this …