Environmental enrichment (EE) is known to profoundly affect the central nervous system
(CNS) at the functional, anatomical and molecular level, both during the critical period and …

During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …

We previously obtained evidence for reduced cell proliferation in the dentate gyrus (DG) of
fetuses with Down syndrome (DS), suggesting that the hippocampal hypoplasia seen in …

Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by
reduced number of cortical neurons and brain size. The occurrence of these defects starting …

Down syndrome (DS) is the most common genetic cause of mental disability. Based on the
homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several …

Down syndrome (DS) is associated with neurological complications, including cognitive
deficits that lead to impairment in intellectual functioning. Increased GABA-mediated …

The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …

Down syndrome (DS) is the leading cause of genetically-defined intellectual disability and
congenital birth defects. Despite being one of the first genetic diseases identified, only …

Trisomy 21, one of the most prevalent congenital birth defects, results in a constellation of
phenotypes collectively termed Down syndrome (DS). Mental retardation and motor and …

Evidence in mouse models for Down syndrome (DS) and human fetuses with DS clearly
shows severe neurogenesis impairment in various telencephalic regions, suggesting that …