Active bacterial metabolism is a prerequisite for optimal activity of many classes of
antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic …

Transition metals occupy an essential niche in biological systems. Their electrostatic
properties stabilize substrates or reaction intermediates in the active sites of enzymes, and …

Microbial pathogenesis studies are typically performed with reference strains, thereby
overlooking within-species heterogeneity in microbial virulence. Here we integrated human …

Blood in healthy organisms is seen as a 'sterile'environment: it lacks proliferating microbes.
Dormant or not-immediately-culturable forms are not absent, however, as intracellular …

The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Lag phase represents the earliest and most poorly understood stage of the bacterial growth
cycle. We developed a reproducible experimental system and conducted functional genomic …

Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …

The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

The oral microbiome, the complex ecosystem of microbes inhabiting the human mouth,
harbors several thousands of bacterial types. The proliferation of pathogenic bacteria within …

The human gut microbiota is inextricably linked to health and disease. One important
function of the commensal organisms living in the intestine is to provide colonization …