Chronic inflammation is a key feature of vascular disease states such as atherosclerosis.
Multiple clinical studies have shown that a class of medications termed statins lower …

Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …

Agonist-induced release of endothelial cell specific storage granules, designated Weibel-
Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to …

Acute kidney injury (AKI) occurs in about half of patients in septic shock and the mortality of
AKI with sepsis is extremely high. An effective therapeutic intervention is urgently required …

Thrombin is a multifunctional serine protease generated at the site of vascular injury that
transforms fibrinogen into fibrin, activates blood platelets and elicits multiple effects on a …

This review summarizes the new findings in these pleiotropic effects and describes their
impact on vascular processes. From a Division of Cardiology, University of Naples 'Federico …

Background: Intensive statin therapy reduces major adverse cardiovascular events (MACE),
but the effect on mortality is unclear. Objective: To determine whether intensive statin …

Exercise promotes cardioprotection in both humans and animals not only by reducing risk
factors associated with cardiovascular disease but by reducing myocardial infarction and …

Objective—Widespread death of implanted cells hampers stem cell therapy for acute
myocardial infarction (AMI). Based on the pleiotropic beneficial effects of statins, we …

Significance: Cardiovascular diseases (CVD) represent a major public health burden. High
low-density lipoprotein (LDL)-cholesterol is a recognized pathogenic factor for …