As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …

The human mitochondrial genome is extremely small compared with the nuclear genome,
and mitochondrial genetics presents unique clinical and experimental challenges. Despite …

Mitochondrial DNA (mtDNA) copy number regulation is altered in several human mtDNA-
mutation diseases and it is also important in a variety of normal physiological processes …

The mitochondrion was originally a free-living prokaryotic organism, which explains the
presence of a compact mammalian mitochondrial DNA (mtDNA) in contempory mammalian …

▪ Abstract DNA polymerase (pol) γ is the sole DNA polymerase in animal mitochondria.
Biochemical and genetic evidence document a key role for pol γ in mitochondrial DNA …

Many years of extensive studies of metazoan mitochondrial genomes have established
differences in gene arrangements and genetic codes as valuable phylogenetic markers …

Mitochondrial DNA (mtDNA) deletions are a primary cause of mitochondrial disease and are
likely to have a central role in the aging of postmitotic tissues. Understanding the mechanism …

Mitochondrial transcription factor A (TFAM), a transcription factor for mitochondrial DNA
(mtDNA) that also possesses the property of nonspecific DNA binding, is essential for …

Elucidation of the process of DNA replication in mitochondria is in its infancy. For many
years, maintenance of the mitochondrial genome was regarded as greatly simplified …

Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are
closely regulated, and imbalances in the four dNTP pools have genotoxic consequences …