Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …

The nuclear factor (NF)-κB is considered the master regulator of inflammatory responses.
Studies in mouse models have established this transcription factor as an important mediator …

Nuclear erythroid-related factor 2 (Nrf2), a redox-sensitive transcription factor, is involved in
transcriptional regulation of many antioxidant genes, including glutamate-cysteine ligase …

The mammalian target of rapamycin (mTOR) regulates cell growth and survival and exists as
rapamycin-sensitive mTOR complex (mTORC) 1 and as rapamycin-insensitive mTORC2 …

Patients with systemic lupus erythematosus (SLE) are found to be accompanied with innate
immunity dysregulation including abnormally macrophage activation. But the functional …

The mammalian target of rapamycin (mTOR) is an evolutionary conserved serine–threonine
kinase that senses various environmental stimuli in most cells primarily to control cell …

T cell memory plays a critical role in our protection against pathogens and tumors. The
antigen and its interaction with the T cell receptor (TCR) is one of the initiating elements that …

Non-coding RNAs (ncRNAs) play important roles in host-pathogen interactions; oncogenic
viruses like Kaposi's sarcoma herpesvirus (KSHV) employ ncRNAs to establish a latent …

Mammalian target of rapamycin inhibitors (mTORi) have clinically significant activity against
various malignancies, such as renal cell carcinoma and breast cancer, but their use can be …

mTOR complex 1 (mTORC1) plays a central role in cell growth and cellular responses to
metabolic stress. Although mTORC1 has been shown to be activated after Toll-like receptor …