Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …

Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …

A hypothetical model of Alzheimer's disease (AD) as a uniquely human brain disorder
rooted in its exceptional process of myelination is presented. Cortical regions with the most …

Late-onset sporadic Alzheimer's disease is a heterogeneous disorder. In elderly patients,
increasing evidence suggests a link between this neurodegenerative disease, and vascular …

The brain contains 2 major groups of dopamine neurons. One is located in the arcuate
nucleus of the hypothalamic median eminence and is involved in neuroendocrine …

Ageing is accompanied by increasing vulnerability to major pathologies (atherosclerosis,
Alzheimer's disease, age-related macular degeneration, cataract, and osteoporosis) which …

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia and
affects up to 15 million people worldwide. Although no single cause of AD has been …

Cholesterol 24-hydroxylase is a highly conserved cytochrome P450 that is responsible for
the majority of cholesterol turnover in the vertebrate central nervous system. The enzyme is …

The present review describes the transgenic mouse models that have been designed to
evaluate the functions of the cytochrome P450s involved in cholesterol and bile acid …

Alpha-tocopherol, one of the eight isoforms of vitamin E, is the most potent fat-soluble
antioxidant known in nature. For years, it was thought that α-tocopherol only functioned as a …