[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

MG Cox, TP Peacock, WT Harvey, J Hughes… - Nature Reviews …, 2023 - nature.com
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19
and are especially important in high-risk individuals where vaccination is not an option …

[HTML][HTML] Omicron variant (B. 1.1. 529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?

M Dhawan, ARA Saied, S Mitra, FA Alhumaydhi… - Biomedicine & …, 2022 - Elsevier
Since the start of the COVID-19 pandemic, numerous variants of SARS-CoV-2 have been
reported worldwide. The advent of variants of concern (VOCs) raises severe concerns amid …

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades

B Dadonaite, J Brown, TE McMahon, AG Farrell… - Nature, 2024 - nature.com
SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …

Humoral immune evasion of the omicron subvariants BQ. 1.1 and XBB

R Uraki, M Ito, Y Furusawa, S Yamayoshi… - The Lancet Infectious …, 2023 - thelancet.com
Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention,
Shandong and else where. BQ. 1.1 and XBB possess substitutions relative to BA. 5 and BA …

In vitro efficacy of antiviral agents against Omicron subvariant BA. 4.6

E Takashita, S Yamayoshi, P Halfmann… - … England Journal of …, 2022 - Mass Medical Soc
In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6 | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

[HTML][HTML] Reversal of the unique Q493R mutation increases the affinity of Omicron S1-RBD for ACE2

AM Philip, WS Ahmed, KH Biswas - Computational and Structural …, 2023 - Elsevier
Abstract The SARS-CoV-2 Omicron variant containing 15 mutations, including the unique
Q493R, in the spike protein receptor binding domain (S1-RBD) is highly infectious. While …

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron

R Maeda, J Fujita, Y Konishi, Y Kazuma… - Communications …, 2022 - nature.com
We are amid the historic coronavirus infectious disease 2019 (COVID-19) pandemic.
Imbalances in the accessibility of vaccines, medicines, and diagnostics among countries …

[HTML][HTML] Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades

B Dadonaite, J Brown, TE McMahon, AG Farrell… - biorxiv, 2023 - ncbi.nlm.nih.gov
SARS-CoV-2 variants acquire mutations in spike that promote immune evasion and impact
other properties that contribute to viral fitness such as ACE2 receptor binding and cell entry …

The spike protein of SARS-CoV-2 is adapting because of selective pressures

GI López-Cortés, M Palacios-Pérez, HF Veledíaz… - Vaccines, 2022 - mdpi.com
The global scale of the COVID-19 pandemic has demonstrated the evolution of SARS-CoV-
2 and the clues of adaptation. After two years and two months since the declaration of the …

The SARS-CoV-2 Omicron recombinant subvariants XBB, XBB. 1, and XBB. 1.5 are expanding rapidly with unique mutations, antibody evasion, and immune escape …

C Chakraborty, M Bhattacharya, H Chopra… - … Journal of Surgery, 2023 - journals.lww.com
Several subvariants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron variant have evolved very quickly and are also evolving continuously. Notably …