Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

First-row transition-metal-mediated reactions constitute an important and growing area of
research due to the low cost, low toxicity, and exceptional synthetic versatility of these …

The addition of a variety of radicals to the double bond of N-(arylsulfonyl) acrylamides can
trigger cyclization/aryl migration/desulfonylation cascades via amidyl radical intermediates …

Covering: 2011–2017 Radical cyclizations have a rich history in organic chemistry and have
been particularly generous to the field of natural product synthesis. Owing to their ability to …

We report the first total synthesis of hypersampsone M, an archetypal member of the
homoadamantane polycyclic polyprenylated acylphloroglucinols (PPAPs). Commencing …

The preceding four decades have witnessed a major expansion in the field of free-radical
assisted reactions, as they are becoming a key tool in organic, polymer and complex natural …

Hyperisampsins A–D (1–4), with tetracyclo [6.3. 1.13, 10.03, 7] tridecane skeletons and
seven biogenetically related congeners (5–11), were isolated from Hypericum sampsonii …

Conspectus Natural products are biosynthesized from a limited pool of starting materials via
pathways that obey the same chemical logic as textbook organic reactions. Given the …

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural
product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled …