The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

P Nombela, B Miguel-López, S Blanco - Molecular cancer, 2021 - Springer
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

Emerging roles of tRNA-derived fragments in cancer

M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

RNA modifications regulating cell fate in cancer

S Delaunay, M Frye - Nature cell biology, 2019 - nature.com
The deposition of chemical modifications into RNA is a crucial regulator of temporal and
spatial gene expression programs during development. Accordingly, altered RNA …

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

P Schimmel - Nature reviews Molecular cell biology, 2018 - nature.com
The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Synonymous but not silent: the codon usage code for gene expression and protein folding

Y Liu, Q Yang, F Zhao - Annual review of biochemistry, 2021 - annualreviews.org
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes

W Zhang, M Foo, AM Eren, T Pan - Molecular Cell, 2022 - cell.com
Summary tRNA is the most extensively modified RNA in cells. On average, a bacterial tRNA
contains 8 modifications per molecule and a eukaryotic tRNA contains 13 modifications per …

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans

L Xu, X Liu, N Sheng, KS Oo, J Liang… - Journal of Biological …, 2017 - ASBMB
Chemical RNA modifications are central features of epitranscriptomics, highlighted by the
discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA …

RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions

L Ayadi, A Galvanin, F Pichot, V Marchand… - Biochimica et Biophysica …, 2019 - Elsevier
Methylation of riboses at 2′-OH group is one of the most common RNA modifications found
in number of cellular RNAs from almost any species which belong to all three life domains …

Functions of bacterial tRNA modifications: from ubiquity to diversity

V de Crécy-Lagard, M Jaroch - Trends in Microbiology, 2021 - cell.com
Modified nucleotides in tRNA are critical components of the translation apparatus, but their
importance in the process of translational regulation had until recently been greatly …

Quantitative mapping of the cellular small RNA landscape with AQRNA-seq

JF Hu, D Yim, D Ma, SM Huber, N Davis… - Nature …, 2021 - nature.com
Current next-generation RNA-sequencing (RNA-seq) methods do not provide accurate
quantification of small RNAs within a sample, due to sequence-dependent biases in capture …