Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …

Malfunction of nuclear–cytoplasmic transport contributes to many diseases including cancer.
Defective nuclear transport leads to changes in both the physiological levels and temporal …

The transport of proteins across the nuclear membrane is a highly regulated process,
essential for the cell function. This transport is actively mediated by members of the …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Signal recognition particle (SRP) is an RNA and protein complex that exists in all domains of
life. It consists of one protein and one noncoding RNA in some bacteria. It is more complex …

The growing cost of medical care worldwide, particularly in oncology, has incentivized
researchers and physicians to repurpose clinically used drugs to alleviate the financial …

Viruses have transformed our understanding of mammalian RNA processing, including
facilitating the discovery of the methyl-7-guanosine (m7G) cap on the 5′ end of RNAs. The …

Methyl-7-guanosine (m7G)“capping” of coding and some noncoding RNAs is critical for their
maturation and subsequent activity. Here, we discovered that eukaryotic translation initiation …