Chromatin plays a crucial role in genome compaction and is fundamental for regulating
multiple nuclear processes. Nucleosomes, the basic building blocks of chromatin, are …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

Histone variants represent chromatin components that diversify the structure and function of
the genome. The variants of H2A, primarily H2A. X, H2A. Z and macroH2A, are well …

Histone proteins are highly conserved among all eukaryotes. They have two important
functions in the cell: to package the genomic DNA and to regulate gene accessibility …

DNA double strand breaks (DSBs) are repaired in eukaryotes by one of several cellular
mechanisms. The decision-making process controlling DSB repair takes place at the step of …

Nucleosomes containing the histone variant H2A. Z are important for gene transcription
initiation and termination, chromosome segregation and DNA double-strand break repair …

The Plasmodium falciparum alternative histones Pf H2A. Z and Pf H2B. Z are enriched in the
same nucleosomes in intergenic euchromatin but depleted from heterochromatin. They …

SUV420H1 di-and tri-methylates histone H4 lysine 20 (H4K20me2/H4K20me3) and plays
crucial roles in DNA replication, repair, and heterochromatin formation. It is dysregulated in …

Chromatin, the functional organization of DNA with histone proteins in eukaryotic nuclei, is
the tightly-regulated template for several biological processes, such as transcription …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …