Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Abstract Summary Cyclophilins (Enzyme Commission (EC) number 5.1. 2.8) belong to a
group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are …

Proline is unique in the realm of amino acids in its ability to adopt completely distinct cis and
trans conformations, which allows it to act as a backbone switch that is controlled by prolyl …

A significant fraction of every proteome is occupied by biologically active proteins that do not
form unique three-dimensional structures. These intrinsically disordered proteins (IDPs) and …

Peptidyl-prolyl isomerases catalyze the conversion between cis and trans isomers of proline.
The cyclophilin family of peptidyl-prolyl isomerases is well known for being the target of the …

Viruses depend on host-derived factors for their efficient genome replication. Here, we
demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B …

The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …

▪ Abstract The Tec family tyrosine kinases are now recognized as important mediators of
antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec …

Background. Long-term immunosuppression imposes increased malignancy risk in renal
allograft recipients, significantly contributing to overall morbidity and mortality. This study …

Pancreatic cancer is a rapidly fatal disease, and there is an urgent need for early detection
markers and novel therapeutic targets. The current study has used a proteomic approach of …