Astrocyte activation in neurovascular damage and repair following ischaemic stroke

A Patabendige, A Singh, S Jenkins, J Sen… - International journal of …, 2021 - mdpi.com
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

Diagnostic and therapeutic potential of exosomes in Alzheimer's disease

T Soares Martins, D Trindade, M Vaz… - Journal of …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles released by almost all cell types in physiological
and pathological conditions. The exosomal potential to unravel disease mechanisms, or to …

The emerging role of neural cell-derived exosomes in intercellular communication in health and neurodegenerative diseases

L Huo, X Du, X Li, S Liu, Y Xu - Frontiers in Neuroscience, 2021 - frontiersin.org
Intercellular communication in the central nervous system (CNS) is essential for brain
growth, development, and homeostasis maintenance and, when dysfunctional, is involved in …

A new paradigm for diagnosis of neurodegenerative diseases: peripheral exosomes of brain origin

N Younas, LC Fernandez Flores, F Hopfner… - Translational …, 2022 - Springer
Neurodegenerative diseases are a heterogeneous group of maladies, characterized by
progressive loss of neurons. These diseases involve an intricate pattern of cross-talk …

[HTML][HTML] Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?

X Xia, Y Wang, Y Qin, S Zhao, JC Zheng - Ageing research reviews, 2022 - Elsevier
Neurotransmission is the electrical impulse-triggered propagation of signals between
neurons or between neurons and other cell types such as skeletal muscle cells. Recent …

In vivo Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates

LJ Ge, FH Yang, W Li, T Wang, Y Lin, J Feng… - Frontiers in cell and …, 2020 - frontiersin.org
Stroke may cause severe death and disability but many clinical trials have failed in the past,
partially because the lack of an effective method to regenerate new neurons after stroke. In …

Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease

L Leggio, F L'Episcopo, A Magrì… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are emerging as powerful players in cell‐to‐cell communication
both in healthy and diseased brain. In Parkinson's disease (PD)—characterized by selective …

[HTML][HTML] Astrocyte-derived extracellular vesicles: A double-edged sword in central nervous system disorders

S Zhao, S Sheng, Y Wang, L Ding, X Xu, X Xia… - Neuroscience & …, 2021 - Elsevier
Recent studies suggest that astrocytes released a great quantity of EVs (AEVs) to
communicate with other brain cells. Under pathological conditions, AEVs are widely …

[HTML][HTML] Extracellular Vesicles in neural cell interaction and CNS homeostasis

A Schnatz, C Müller, A Brahmer… - FASEB …, 2021 - ncbi.nlm.nih.gov
Central nervous system (CNS) homeostasis critically depends on the interaction between
neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile …

Exosomes: innocent bystanders or critical culprits in neurodegenerative diseases

M Beatriz, R Vilaça, C Lopes - Frontiers in cell and Developmental …, 2021 - frontiersin.org
Extracellular vesicles (EVs) are nano-sized membrane-enclosed particles released by cells
that participate in intercellular communication through the transfer of biologic material. EVs …