Oxidative stress has been linked with a variety of diseases, being involved in the debut
and/or progress of several neurodegenerative disorders. This review intends to summarize …

Advanced glycation end products (AGEs) are formed in non-enzymatic reaction, oxidation,
rearrangement and cross-linking between the active carbonyl groups of reducing sugars …

Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Autism Spectrum Disorders (ASDs) represent a group of neurodevelopmental disorders
associated with social and behavioral impairments. Although dysfunctions in several …

Microglial NLRP3 inflammasome activation is emerging as a key contributor to
neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β …

Neurodegenerative disorders affect more than fifty million Americans each year and
represent serious health threats as the population ages. Neuroinflammation and oxidative …

Microglia are specialized dynamic immune cells in the central nervous system (CNS) that
plays a crucial role in brain homeostasis and in disease states. Persistent …

Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …