The IRE1α-XBP1 signaling axis promotes glycolytic reprogramming in response to inflammatory stimuli
BC English, HP Savage, SP Mahan, VE Diaz-Ochoa… - MBio, 2023 - Am Soc Microbiol
Immune cells must be able to adjust their metabolic programs to effectively carry out their
effector functions. Here, we show that the endoplasmic reticulum (ER) stress sensor Inositol …
effector functions. Here, we show that the endoplasmic reticulum (ER) stress sensor Inositol …
Chlamydia trachomatis TmeA directly activates N-WASP to promote actin polymerization and functions synergistically with TarP during invasion
G Keb, J Ferrell, KR Scanlon, TJ Jewett, KA Fields - MBio, 2021 - Am Soc Microbiol
Chlamydia trachomatis is a medically significant human pathogen and is an epithelial-tropic
obligate intracellular parasite. Invasion of nonprofessional phagocytes represents a crucial …
obligate intracellular parasite. Invasion of nonprofessional phagocytes represents a crucial …
Regulation of the mitochondrion-fatty acid axis for the metabolic reprogramming of Chlamydia trachomatis during treatment with β-lactam antimicrobials
K Shima, I Kaufhold, T Eder, N Käding, N Schmidt… - MBio, 2021 - Am Soc Microbiol
Infection with the obligate intracellular bacterium Chlamydia trachomatis is the most
common bacterial sexually transmitted disease worldwide. Since no vaccine is available to …
common bacterial sexually transmitted disease worldwide. Since no vaccine is available to …
Orientia tsutsugamushi infection reduces host gluconeogenic but not glycolytic substrates
SE Sanchez, TJ Chiarelli, MA Park… - Infection and …, 2024 - journals.asm.org
Orientia tsutsugamushi a causal agent of scrub typhus, is an obligate intracellular bacterium
that, akin to other rickettsiae, is dependent on host cell-derived nutrients for survival and thus …
that, akin to other rickettsiae, is dependent on host cell-derived nutrients for survival and thus …
A “plus one” strategy impacts replication of felid alphaherpesvirus 1, Mycoplasma and Chlamydia, and the metabolism of coinfected feline cells
Coinfections are known to play an important role in disease progression and severity.
Coinfections are common in cats, but no coinfection studies have investigated the in vitro …
Coinfections are common in cats, but no coinfection studies have investigated the in vitro …