Aerosol transport modeling: the key link between lung infections of individuals and populations

C Darquenne, AAT Borojeni, MJ Colebank… - Frontiers in …, 2022 - frontiersin.org
The recent COVID-19 pandemic has propelled the field of aerosol science to the forefront,
particularly the central role of virus-laden respiratory droplets and aerosols. The pandemic …

Causes and consequences of spatial within-host viral spread

ME Gallagher, CB Brooke, R Ke, K Koelle - Viruses, 2018 - mdpi.com
The spread of viral pathogens both between and within hosts is inherently a spatial process.
While the spatial aspects of viral spread at the epidemiological level have been increasingly …

Iterative community-driven development of a SARS-CoV-2 tissue simulator

M Getz, Y Wang, G An, M Asthana, A Becker… - BioRxiv, 2020 - biorxiv.org
The 2019 novel coronavirus, SARS-CoV-2, is an emerging pathogen of critical significance
to international public health. Knowledge of the interplay between molecular-scale virus …

Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

MA Myers, AP Smith, LC Lane, DJ Moquin, R Aogo… - Elife, 2021 - elifesciences.org
Influenza viruses cause a significant amount of morbidity and mortality. Understanding host
immune control efficacy and how different factors influence lung injury and disease severity …

An agent-based modeling approach for lung fibrosis in response to COVID-19

MA Islam, M Getz, P Macklin… - PLOS Computational …, 2023 - journals.plos.org
The severity of the COVID-19 pandemic has created an emerging need to investigate the
long-term effects of infection on patients. Many individuals are at risk of suffering pulmonary …

Antibody protection from SARS-CoV-2 respiratory tract exposure and infection

A Chen, T Wessler, MG Forest - Journal of Theoretical Biology, 2023 - Elsevier
The COVID-19 pandemic has underscored the need to understand the dynamics of SARS-
CoV-2 respiratory infection and protection provided by the immune response. SARS-CoV-2 …

Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection

ME Moses, S Hofmeyr, JL Cannon… - PLoS computational …, 2021 - journals.plos.org
A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary
dramatically across individuals. Because spatial-temporal dynamics of viral spread and …

Spatiotemporal dynamics of virus infection spreading in tissues

G Bocharov, A Meyerhans, N Bessonov, S Trofimchuk… - PLoS …, 2016 - journals.plos.org
Virus spreading in tissues is determined by virus transport, virus multiplication in host cells
and the virus-induced immune response. Cytotoxic T cells remove infected cells with a rate …

GPU acceleration and data fitting: agent-based models of viral infections can now be parameterized in hours

BG Fain, HM Dobrovolny - Journal of computational science, 2022 - Elsevier
For many years, infectious disease modelers have used agent-based models to study the
spread of viruses, but the models were too computationally intensive to fully replicate even …

A framework for designing compassionate and ethical artificial intelligence and artificial consciousness

S Banerjee - Interdisciplinary Description of Complex Systems …, 2020 - hrcak.srce.hr
Sažetak Intelligence and consciousness have fascinated humanity for a long time and we
have long sought to replicate this in machines. In this work, we show some design principles …