Vaccines play an essential role in controlling the rates of fatality and morbidity. Vaccines not
only arrest the beginning of different diseases but also assign a gateway for its elimination …

Computational protein engineering has enabled the rational design of customized proteins,
which has propelled both sequence-based and structure-based immunogen engineering …

How HIV-1 entry mechanism and broadly neutralizing antibodie... : Current Opinion in HIV and
AIDS How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based …

It has been twenty years since the first rationally designed small molecule drug was
introduced into the market. Since then, we have progressed from designing small molecules …

Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike
protein, which continually mutates to escape acquired immunity. Other regions in the spike …

Background Antibodies are composed of light and heavy chains, both of which have
constant and variable regions. The diversity, specific binding ability and therapeutic potential …

Vaccination has proven to be an invaluable means of preventing infectious diseases by
reducing both incidence of disease and mortality. However, vaccines have not been …

Two alternative strategies are commonly used to study protein–protein interactions (PPIs)
and to engineer protein-based inhibitors. In one approach, binders are selected …

Antibodies are one of the most important protein molecules in biopharmaceutics. Due to the
recent advance in technology for producing monoclonal antibodies, many structural data are …

Computational antibody engineering efforts to date have focused on improving binding
affinities or biophysical characteristics. De novo design of antibodies binding specific …