A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

We recently reported that HIV-1 cores that retained> 94% of their capsid (CA) protein
entered the nucleus and disassembled (uncoated) near their integration site< 1.5 h before …

Increasing evidence suggests that chromatin modifications have important roles in
modulating constitutive or alternative splicing. Here we demonstrate that the PWWP domain …

HIV DNA integration is favored in active genes, but the underlying mechanism is unclear.
Cellular lens epithelium-derived growth factor (LEDGF/p75) binds both chromosomal DNA …

Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide
crucial functions for lentiviral nuclear entry and integration. We previously showed that the …

Menin displays the unique ability to either promote oncogenic function in the hematopoietic
lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular …

Chromosomal integration enables human immunodeficiency virus (HIV) to establish a
permanent reservoir that can be therapeutically suppressed but not eradicated. Participation …

LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …

Integrase (IN) is an essential retroviral enzyme, and human transcriptional coactivator p75,
which is also referred to as lens epithelium-derived growth factor (LEDGF), is the dominant …