Regulation of inflammation by the antioxidant haem oxygenase 1

NK Campbell, HK Fitzgerald, A Dunne - Nature Reviews Immunology, 2021 - nature.com
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

The biochemistry and medical significance of the flavonoids

BH Havsteen - Pharmacology & therapeutics, 2002 - Elsevier
Flavonoids are plant pigments that are synthesised from phenylalanine, generally display
marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are …

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

HP Harding, Y Zhang, H Zeng, I Novoa, PD Lu… - Molecular cell, 2003 - cell.com
Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress),
amino acid starvation, or oxidants by phosphorylating the α subunit of translation initiation …

Role of oxidative modifications in atherosclerosis

R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

DM Hockenbery, ZN Oltvai, XM Yin, CL Milliman… - Cell, 1993 - cell.com
Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality.
Bcl-2 is localized to intracellular sites of oxygen free radical generation including …

Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingerprints, and detection limits

C Wang, P Sahay - Sensors, 2009 - mdpi.com
Breath analysis, a promising new field of medicine and medical instrumentation, potentially
offers noninvasive, real-time, and point-of-care (POC) disease diagnostics and metabolic …

Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure

SJS Flora - Oxidative medicine and cellular longevity, 2009 - Wiley Online Library
Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid.
Beneficial renal effects of some medications, such as chelation therapy depend at least …

Mechanisms of action of arsenic trioxide

WH Miller Jr, HM Schipper, JS Lee, J Singer… - Cancer research, 2002 - AACR
Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and
relapsedpatients with acute promyelocytic leukemia (APL). As a single agent, it induces …

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

AM Choi, J Alam - American journal of respiratory cell and molecular …, 1996 - atsjournals.org
Accumulating evidence suggests that oxidative stress plays a central role in the
pathogenesis of many pulmonary diseases including adult respiratory distress syndrome …