Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Centrosomes and primary cilia are usually considered as distinct organelles, although both
are assembled with the same evolutionary conserved, microtubule-based templates, the …

Because DNA double-strand breaks (DSBs) greatly threaten genomic integrity, effective
DNA damage sensing and repair are essential for cellular survival in all organisms …

Aurora-A is an essential cell-cycle kinase with critical roles in mitotic entry and spindle
dynamics. These functions require binding partners such as CEP192 and TPX2, which …

In the final stage of oogenesis, mammalian oocytes generate a meiotic spindle and undergo
chromosome segregation to yield an egg that is ready for fertilization. Herein, we describe …

Human cancers share requirements for phosphorylation-dependent signaling, mitotic
hyperactivity, and survival after DNA damage. The oncoprotein CIP2A (cancerous inhibitor …

Errors during meiotic resumption in oocytes can result in chromosome missegregation and
infertility. Several cell cycle kinases have been linked with roles in coordinating events …

The cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein found
overexpressed in many types of cancer. CIP2A has been shown to stabilize oncoproteins …

Diesel exhaust particles (DEPs) are major components of ambient particulate matter and are
associated with various adverse health effects. Typically, DEPs contain a vast number of …

As a highly conserved and ubiquitously expressed serine/threonine kinase, p21-activated
kinase 2 (PAK2) participates in diverse biologic events. However, its roles in mouse oocyte …