Withanolides represent an important category of natural products with a steroidal lactone
core. Many of them contain an α, β-unsaturated carbonyl moiety with a high reactivity toward …

Disease relapse and therapy resistance remain key challenges in treating multiple
myeloma. Underlying (epi-) mutational events can promote myelomagenesis and contribute …

Withania somnifera (L.) Dunal, abundant in the Indian subcontinent as Ashwagandha or
winter cherry, is a herb of unprecedented therapeutic value. The number of ailments for …

Interest in covalent drug discovery has surged in recent years, following the high-profile FDA
approvals of covalent inhibitors that target BTK and KRAS G12C. High-throughput screening …

Multiple myeloma (MM), second most common hematological malignancy, still remains
irremediable because of acquisition of drug resistance. Glucocorticoid (GC) therapy, which …

Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used
extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine …

Through phosphorylation of their substrate proteins, protein kinases are crucial for
transducing cellular signals and orchestrating biological processes, including cell death and …

Protein kinases (PK) make up around 2% of the human genome and their expression profile
varies depending on the organ and tissue. They play crucial roles in intracellular signaling …

Accessing the collection of perturbed gene expression profiles, such as the LINCS L1000
connectivity map, is usually performed at the individual dataset level, followed by a summary …

Ferroptosis is a lipid peroxidation-dependent mechanism of regulated cell death known to
suppress tumor proliferation and progression. Although several genetic and protein …