Background Endoscopic skull‐base surgery (ESBS) is employed in the management of
diverse skull‐base pathologies. Paralleling the increased utilization of ESBS, the literature in …

Background Patients suffering from malignant gliomas have a poor prognosis. For the
surgical treatment of these tumors, 5‐aminolevulinic acid (5‐ALA) has become a new …

Fluorescence-guided surgery (FGS) allows surgeons to have improved visualization of
tumor tissue in the operating room, enabling maximal safe resection of malignant brain …

OBJECT Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin
IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide …

Abstract Recently, 5-aminolevulinic acid (5-ALA) has been utilized as an adjuvant to the
surgical resection of primary brain tumors and metastases. We conducted a systematic …

Glial tumors are one of the most common lesions of the central nervous system. Despite the
implementation of appropriate treatment, the prognosis is not successful. As shown in the …

Background Intraoperative identification of pulmonary nodules, particularly small lesions,
can be challenging. We hypothesize that folate receptor-targeted intraoperative molecular …

5‐aminolevulinic acid (5‐ALA) is a prodrug that results in the fluorescence of high‐grade
gliomas relative to the surrounding brain parenchyma. 5‐ALA has been increasingly utilized …

The most widely used fluorophore in glioma-resection surgery, 5-aminolevulinic acid (5-
ALA), is thought to cause the selective accumulation of fluorescent protoporphyrin IX (PpIX) …

However, the use of 5-ALA has also several distinct disadvantages. 5-ALA is expensive, and
its use must still be approved by the American Food and Drug Administration (FDA) …