Ultrafast magic angle spinning solid-state NMR spectroscopy: Advances in methodology and applications

Y Nishiyama, G Hou, V Agarwal, Y Su… - Chemical …, 2022 - ACS Publications
Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques

E Pindelska, A Sokal, W Kolodziejski - Advanced drug delivery reviews, 2017 - Elsevier
The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …

De novo 3D structure determination from sub‐milligram protein samples by solid‐state 100 kHz MAS NMR spectroscopy

V Agarwal, S Penzel, K Szekely… - Angewandte Chemie …, 2014 - Wiley Online Library
Solid‐state NMR spectroscopy is an emerging tool for structural studies of crystalline,
membrane‐associated, sedimented, and fibrillar proteins. A major limitation for many studies …

Spinning faster: protein NMR at MAS frequencies up to 126 kHz

S Penzel, A Oss, ML Org, A Samoson… - Journal of biomolecular …, 2019 - Springer
We report linewidth and proton T 1, T 1 ρ and T 2′ relaxation data of the model protein
ubiquitin acquired at MAS frequencies up to 126 kHz. We find a predominantly linear …

Fast magic-angle sample spinning solid-state NMR at 60–100 kHz for natural abundance samples

Y Nishiyama - Solid State Nuclear Magnetic Resonance, 2016 - Elsevier
In spite of tremendous progress made in pulse sequence designs and sophisticated
hardware developments, methods to improve sensitivity and resolution in solid-state NMR …

Understanding surface and interfacial chemistry in functional nanomaterials via solid‐state NMR

A Marchetti, J Chen, Z Pang, S Li, D Ling… - Advanced …, 2017 - Wiley Online Library
Surface and interfacial chemistry is of fundamental importance in functional nanomaterials
applied in catalysis, energy storage and conversion, medicine, and other nanotechnologies …

Protein resonance assignment at MAS frequencies approaching 100 kHz: a quantitative comparison of J-coupling and dipolar-coupling-based transfer methods

S Penzel, AA Smith, V Agarwal, A Hunkeler… - Journal of biomolecular …, 2015 - Springer
We discuss the optimum experimental conditions to obtain assignment spectra for solid
proteins at magic-angle spinning (MAS) frequencies around 100 kHz. We present a …

Proton-detected solid-state NMR spectroscopy of bone with ultrafast magic angle spinning

KH Mroue, Y Nishiyama, M Kumar Pandey, B Gong… - Scientific reports, 2015 - nature.com
While obtaining high-resolution structural details from bone is highly important to better
understand its mechanical strength and the effects of aging and disease on bone …

[PDF][PDF] Exploring the salt–cocrystal continuum with solid-state NMR using natural-abundance samples: implications for crystal engineering

L Rajput, M Banik, JR Yarava, S Joseph, MK Pandey… - IUCrJ, 2017 - journals.iucr.org
There has been significant recent interest in differentiating multicomponent solid forms, such
as salts and cocrystals, and, where appropriate, in determining the position of the proton in …

Natural abundance 14 N and 15 N solid-state NMR of pharmaceuticals and their polymorphs

SL Veinberg, KE Johnston, MJ Jaroszewicz… - Physical Chemistry …, 2016 - pubs.rsc.org
14N ultra-wideline (UW), 1H {15N} indirectly-detected HETCOR (idHETCOR) and 15N
dynamic nuclear polarization (DNP) solid-state NMR (SSNMR) experiments, in combination …