Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

[HTML][HTML] Consequences of genomic diversity in Mycobacterium tuberculosis

M Coscolla, S Gagneux - Seminars in immunology, 2014 - Elsevier
The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Co‐evolution of Mycobacterium tuberculosis and Homo sapiens

D Brites, S Gagneux - Immunological reviews, 2015 - Wiley Online Library
The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

Q Wang, HIM Boshoff, JR Harrison, PC Ray, SR Green… - Science, 2020 - science.org
Mycobacterium tuberculosis has an unusual outer membrane that lacks canonical porin
proteins for the transport of small solutes to the periplasm. We discovered that 3, 3-bis-di …

Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

S Fishbein, N Van Wyk, RM Warren… - Molecular …, 2015 - Wiley Online Library
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Calcium binding proteins and calcium signaling in prokaryotes

DC Domínguez, M Guragain, M Patrauchan - Cell calcium, 2015 - Elsevier
With the continued increase of genomic information and computational analyses during the
recent years, the number of newly discovered calcium binding proteins (CaBPs) in …

Methodological and clinical aspects of the molecular epidemiology of Mycobacterium tuberculosis and other mycobacteria

T Jagielski, A Minias, J van Ingen… - Clinical microbiology …, 2016 - Am Soc Microbiol
Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

Q Chai, X Wang, L Qiang, Y Zhang, P Ge, Z Lu… - Nature …, 2019 - nature.com
Ubiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host
defense against intracellular pathogens including Mycobacterium tuberculosis (Mtb) …

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47

NK Saini, A Baena, TW Ng, MM Venkataswamy… - Nature …, 2016 - nature.com
Suppression of major histocompatibility complex (MHC) class II antigen presentation is
believed to be among the major mechanisms used by Mycobacterium tuberculosis to …

New insights into the mycobacterial PE and PPE proteins provide a framework for future research

LS Ates - Molecular microbiology, 2020 - Wiley Online Library
The PE and PPE proteins of Mycobacterium tuberculosis have been studied with great
interest since their discovery. Named after the conserved proline (P) and glutamic acid (E) …